Nadia Elsahli, Nourz. A.Gheriani, Amina Beayou, Naima ELwarfali
Haematology & Oncology Unit; Children Hospital, Faculty of Medicine, University of Garyounis, Benghazi-Libya
JMJ Vo1.7 No.1 (Spring) 2007:31-35
Objective: To determine the epidemiological pattern, treatment and outcome of kidney Tumours in Libyan children. Patients & Methods: A retrospective study was carried out on all patients with kidney Tumours (n=30) treated at Oncology Unit in Al-Fateh hospital from January 1995 to December 2004. Results: Twenty-seven patients (90%) had Wilms’ Tumours and 3(10%) had non-Wilms’ Tumours (congenital mesoblastic nephroma, clear cell sarcoma and renal cell carcinoma). Fifty percent of the total and 48% of patients with Wilms’ Tumours were from East to Benghazi area (Elmarj, Elbeida, Derna and Tobreq). The mean age for Wilms’ Tumours was 40 months and male to female ratio was 0.8:1. Hemi hypertrophy was observed in 2 patients. Sixty-seven percent were in stages I & II and most had favourable histology (25/27). All patients were treated according to National Wilms’ Tumours Study group (NWTSG). Seven patients (26%) relapsed in a mean of 18 months. The estimated 4-year overall survival (OS) and disease-free survival (DFS) rates for patients with Wilms’ Tumours in all stages were 81% ± 15.4% and 70% ± 17.6% respectively. All the 3 patients with non-Wilms’ Tumours are disease-free. Conclusion: We observed that the pattern of kidney Tumours is similar to other studies except it showed Slight female predominance, less associated with congenital abnormalities and the disease is more advanced with relatively poor outcome. We recommend closed rather than open biopsy with more intensive therapy for inoperable Tumours at diagnosis. Moreover, health education should be offered to medical staff and the target public about early detection of the Tumours which is crucial for cure.
Keywords: Kidney Tumours, Wilms’ Tumours, Advanced, Closed biopsy.