A follow-up study of renal transplant patients in the eastern part of Libya

Original article


S.M Hussein, A M. Shermaddo, A J. Daghily, F M. Sheibani

Faculty of Medicine, Garyounis University, Nephrology Centre, Benghazi, Libya

JMJ Vol. 2, No. 2 (September 2002): 41-43


In this study, we report our experience in the following up of 141 renal transplant patients at Benghazi Nephrology Centre. Ninety-five patients (67.4%) received living non-related transplant (LNRT), Forty-two (29.8%) received living -related transplants (LRT) and four (2.8%) received cadaver kidneys. The age of patients at the time of transplantation ranged from 15 to 77 years with a mean of 41.01% years +-13.58SD. The following up period ranged from 2to 286 months with a mean of 76.6 months +-63SD. Thirty patient died of, both transplant – related and non – transplant related conditions, and ten patients were back on dialysis. Diabetes Mellitus was present in twenty-seven patients (19%), twelve (44%) of them is acquired post transplantation, hypertension was present in 86 (61%) patient. The overall prevalence of acute rejection episodes was 29% (forty – one patients) of these episodes were among LRT and 30% (29patients) among LNRT. The major cause of graft loss is chronic allograft nephropathy with a prevalence of 31.9%, the influence of different factors. Such as type of transplant, immunosuppression protocol, Anti hepatitis C antibodies (Anti HCV Abs) and hepatitis B Australia Antigen (HBsAg) positivity, diabetes mellitus, hypertension, occurrence of acute rejection, on outcome were analyzed. We found that the following had significant correlation; history of acute rejection episodes (p<0.001), living non- related transplant (0.01>p<0.05), and serum creatinine at time of transplantation (p<0.05). Keywords: Acute rejection, chronic allograft nephropathy, and transplantation Link/DOI: http://www.jmj.org.ly/modules.php?name=News&file=article&sid=1236