A hypothesis on the role of the human immune system in covid-19



Khashkhosha HK, Elhadi M.


Med Hypotheses. 2020 Oct;143:110066. doi: 10.1016/j.mehy.2020.110066. Epub 2020 Jul 1.


The COVID-19 pandemic has not spared any continent. The disease has affected more than 7,500,000 individuals globally and killed approximately 450,000 individuals. The disease is caused by a very small virus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is an enveloped single-stranded RNA virus with a spike-like structure on its envelope that can interact with the angiotensin-converting enzyme 2 (ACE2) receptor after cleavage. ACE2 receptors are present in the human lungs and other organs. SARS-CoV-2 is a new virus that belongs to the subgenus Sarbecovirus; viruses in this subgenus have spread widely in the previous years and caused outbreaks of severe acute respiratory syndromes. CI – Copyright © 2020 Elsevier Ltd. All rights reserved.

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Link/DOI: 10.1016/j.mehy.2020.110066