A New Perspective on HIV Vaccine Design: A ViewPoint


Bagasra O 1, Pace DG 2

1. Department of Biology Director, South Carolina Center for Biotechnology, Claflin University, Orangeburg, SC, USA 2. Department of English and Foreign Languages, Claflin University, Orangeburg, SC, USA

IJMBS 2010;2(1):1-13


The unsuccessful outcome of a number of vaccine trials in the quest to conquer HIV-1 demonstrates the difficulties inherent in fighting diseases that afflict our world, and disproportionately, especially the developing nations. A quarter century has elapsed since AIDS became a recognized as a major threat to human health, yet the ever-growing volume of scientific data has failed to meet its prime objective, a cure for AIDS or a HIV prevention vaccine. This brief article suggests several intriguing possibilities for researchers to consider, including small RNA-based immunity, as they seek to find a vaccine for the HIV-1 infection which threatens not only individuals and families, but in some cases entire nations.

Keywords: African non-human primates (ANHPs), Classical immunity (CI), Cell-mediated immunity (CMI), elite suppressor (ES), Humoral immunity (HI), innate immunity, long-term nonprogressor (LTNP), microRNAs (miRNAs), molecular immunity (MI), Vaccine

Link/DOI: http://journals.sfu.ca/ijmbs/index.php/ijmbs/article/view/41/125