Original article
English
Emhamed Abdulsalam Emhamed
The National Medical Research Centre, Benghazi office
LJMR. Vol 1, No.1 2002:50-52
Abstract
This 36 months comparative study involved 113 patients with rheumatoid arthritis (RA) signs. Fifteen patients were males (13.2 %) nd 98 females (86.7%) with an overall age range between 22 and 70 years. Ninety seven patients (85.8%) were RF positive. Forty-eight patients had symptoms for less than 2 years (early RA), and 64 for more than 2 years (late RA). Methotrexate (MTX) was administered orally to both early RA and late RA patients, with a dose of 7.5- 30mg. Per week. Patient follow up for markers ofRA activity was made at 8 weekly intervals, and radiology assessment were performed every 3 months, Clinical improvement occurred in 85% of the early RA patients, and in 75% of the late RA patients. Suboptimal response and hepatotoxicity was noted in 4% of the early RA patients, and in 3.1% of the late RA patients.
Keywords: A Prospectwe Comparison Study Of Methotrexate (Mtx In Early And Late Rheumatoid Arthritis (Ra) : Conclusion After(361 Months Of Therapy.
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