A Rare Inherited Balanced Translocation [t (1;2)(p13;q37)] as a Cause of Recurrent Spontaneous Abortions.

Case report

English

Jafar Ali, Saeed Hammad Ali, Fawwaz B. Baker

Batnan Medical Centre Laboratory, Faculty of Medicine, Omer El Mukhtar University, Tobruk, Libya

JMJ Vo1. 8 No.4 (Winter) 2008:300-305

Abstract

We report a 29 year old female who was referred to us with a history of three spontaneous abortions. Her karyotype revealed a balanced translocation 46,XX,t(1;2)(p13;q37). A search of literature failed to reveal any earlier report of this type of translocation as a cause of spontaneous abortions. Rather, the only balanced translocations reported between chromosome 1 and chromosome 2are 46,XX,t(1;2)(p34;q37),46,XX,t(1;2)(p36;q13)and 46,XY,t(1;2)(p36;q37). In our study, a cytogenetic analysis of the first degree relatives revealed a similar translocation 46,XY,t(1;2)(p13;q37)in the father. However the other siblings were not affected.

Keywords: Recurrent abortion, Chromosome1, Chromosome2, Balanced translocation.

Link/DOI: http://www.jmj.org.ly/PDF/winter2008/300.pdf