A Rare Inherited Balanced Translocation [t (1;2)(p13;q37)] as a Cause of Recurrent Spontaneous Abortions.

Case report


Jafar Ali, Saeed Hammad Ali, Fawwaz B. Baker

Batnan Medical Centre Laboratory, Faculty of Medicine, Omer El Mukhtar University, Tobruk, Libya

JMJ Vo1. 8 No.4 (Winter) 2008:300-305


We report a 29 year old female who was referred to us with a history of three spontaneous abortions. Her karyotype revealed a balanced translocation 46,XX,t(1;2)(p13;q37). A search of literature failed to reveal any earlier report of this type of translocation as a cause of spontaneous abortions. Rather, the only balanced translocations reported between chromosome 1 and chromosome 2are 46,XX,t(1;2)(p34;q37),46,XX,t(1;2)(p36;q13)and 46,XY,t(1;2)(p36;q37). In our study, a cytogenetic analysis of the first degree relatives revealed a similar translocation 46,XY,t(1;2)(p13;q37)in the father. However the other siblings were not affected.

Keywords: Recurrent abortion, Chromosome1, Chromosome2, Balanced translocation.

Link/DOI: http://www.jmj.org.ly/PDF/winter2008/300.pdf