Acute bacterial meningitis in clinical practice.



Hisham M Ziglam 1, Anas L Najjar 1, Holly Merrick 2.

1-Department of Infectious Diseases, Central Hospital, Tripoli, Libya 2-Department of Assessment Unit,Manchester Royal Infirmary,Manchester,UK.

Libyan J Infect Dis. 2010;4(1):13-23


Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. It is often challenging for the treating physician because sensitivity and specificity of clinical signs do not reach 100%. Investigations of the cerebrospinal fluid are necessary to confirm or rule out the diagnosis.The principles of antimicrobial therapy for acute bacterial meningitis include use of agents that penetrate well into cerebrospinal fluid and attain appropriate cerebrospinal fluid concentrations and are bactericidal against the infecting pathogen. This article provides an overview of meningitis which can have devastating effects.

Keywords: Meningitis, bacteria, cerebrospinal, Antimicrobial