Antibiotic Susceptibility of Uropathogens in Benghazi, Libya

Original article


RS Tobgi1, IAA Taher2, MB Ali3

1. AL-Fateh Children Hospital,Benghazi, Libya
2. Department of Microbiology, and 3. Department of Medicine, Faculty of Medicine, Garyounis University, Benghazi, Libya

JMJ Vol. 1, No. 2 (November 2001): 46-49


Objectives: To study the antibiotic susceptibility of uropathogens to most commonly used antibacterial agents.
Methods: A total number of 371 bacterial isolate from urine representing both hospitalized and outpatients were tested against eleven antimicrobial agents using standard disc diffusion method. The clinical isolates included E. coli, proteus, Klebsiella and pseudomonas species.
Results: Of the drugs tested, Nalidixic acid and Nitrofurantoin showed excellent activity against most of the uropathogens. However, these isolates were highly resistant to trimethoprim-sulphamethoxazol (85.5%), Ampicillin (85%), Carbenicillin (82.2%), tetracycline (78%), Chloramphenicol (35%) and Gentamicin (34.2%). There was a significant difference between the susceptibility of the different bacteria to these agents. E. coli was the least resistant compared to both pseudomonas and proteus species (p0.007 and o.oo9 respectively). Conclusion: It appears to be alarming that resistance to most widely used antibiotics is increasing, this mandates the band of their use without prior susceptibility testing and stimulates the need for constant periodic evaluation of their antimicrobial activity.

Keywords: Antibiotic resistance; E. coli; Pseudomonas; Klebsiella and Proteus