Association Between Multiple Sclerosis and Neurofibromatosis

Case report


Anwaar M. Bennour, Mahfoud Bashari, Salha Eltaib, Abulhamid Zawawi

Department of Medicine, Neurology Unit, 7th October Hospital, Benghazi, Libya.

JMJ 2008,Vol.8, No.3:225-227


Neurofibromatosis 1 (NF1) is a common autosomal dominant disease that has a wide range of neurological manifestations. The gene for NF1 has been located on chromosome 17q11.2 and there are three embedded genes within the NF1 gene. One of these genes is oligodendrocyte-myelin glycoprotein, which is found in the CNS during myelination, and might contribute to the development of progressive inflammatory white matter disease. We here report a case of NF1 and secondary progressive form of multiple sclerosis, adding a new patient to the previously reported ten cases of this rare and interesting association.

Keywords: Neurofibromatosis, Multiple sclerosis, Oligodendrocyte-myelin glycoprotein “Omgp gene”.