Asthma: Pathogenesis and Management (A Review)



A. Obead and M. Ahmed

Dept of Medicine Al Arab Medical University, Benghazi, Libya

Garyounis Medical Journal Vol. 17, No. 1-2. January/July l994:.94-101


Asthma is a chronic illness that characterised by increased responsiveness of tracheo bronchial tree to multiplicity of stimuli. It is manifested physiologically by widespread narrowing of the tracheobronchiai tree, and clinically by paroxysms of dyspnea, cough and wheezing, that resolve spontaneously or with therapy. It is an episodic disease, acute exacerbation being interspersed in terms of features that purportedly have a role in its pathogenesis and pathophysiology, airway inflammation and bronchial hyperresponsiveness.
Asthma is a common disease affecting approximately 3 to 5 percent of the population. The prevalence and severity of asthma are rising (19). The mortality from asthma has been increasing. The causes of this increase has not been established. Possible reasons include adverse response to 82— agonist therapy, improper assessment of the severity of the episode by the patient, physician or both (26); and inadequate treatment in the hospital. In this article, we shall briefly review pathogenesis and management of asthma.

Keywords: Asthma: Pathogenesis and Management