Department of Laboratory Medicine (Immology Unit), Ahmadu Bello University Hospital, Zaria, Nigeria.
Garyounis Medical Journal Vol. 15. January/July 1992:14-17
The serum levels of circulating immunecomplexes (CICs), immuno globulins (Igs) and complements (Cs) were studied in 20 Nigerian children with Burkitt’s Lymphoma (BL) (age: 4-10 years; 12 males, 8 females). Of these 20 patients, 6 patients had single facial tumor mass (SF141) on left maxilla, 4 patients had SFIM on right maxilla, 6 patients had SFIM on left mandible and 4 patients had SFIM on right mandible. The findings were that mean serum 1gM level in BL was significantly lower than that of control subjects (CS) (P < 0.01), whereas IgG and IgA levels were normal (P> 0.05). In BL, the serum levels of CICs and CS (0, 64) were significantly higher (P < 0.02 and lower (P < 0.05) respectively as compared to controls. It was therefore proposed that the lowered serum 1gM level may be due to virus-induced 1gM-specific T-cell immunosuppression. The decrease levels of Cs were explained as probably due to their increased utilization for clearance of excessive CICs. Keywords: Circulating Immunecomplexes, Immunoglobulins and Complements in Nigerien Children with Burkitt’s Lymphoma Link/DOI: