Clinical features and outcomes of neonatal dengue at the Children’s Hospital 1, Ho Chi Minh, Vietnam



Nguyen TM, Huan VT, Reda A, Morsy S, Nam Giang HT, Tri VD, Mau NK, Elfaituri MK, Hieu TH, Hung NT, Hirayama K, Huy NT.


J Clin Virol. 2021 May;138:104758. doi: 10.1016/j.jcv.2021.104758. Epub 2021 Feb 9.


Objectives Neonatal dengue has been reported in the literature with contradictory findings of clinical characteristics and diagnosis; thereby, misdiagnosis of neonatal dengue has been frequently reported. We aim to delve into the epidemiology, clinical features, and outcomes of neonatal dengue, thus avoid misdiagnosis and obtain early intervention. Study design A retrospective study was conducted at Children’s Hospital 1, Ho Chi Minh, Vietnam with laboratory-confirmed dengue in neonates by positive viral antigen nonstructural protein one rapid test (NS1) and positive IgM antibody for dengue by MAC-ELISA. Results We have included 32 neonates in this study with 25% cases were misdiagnosed with neonatal sepsis, and 12.5% cases were misdiagnosed with neonatal immune thrombocytopenia at the beginning. The median time between the first day of the mother’s onset of fever and childbirth was -1 days (IQR: -2, 2). The patient’s clinical manifestation included: petechiae 87.5% (28/32), pharyngeal mucosal hemorrhage 6.3% (2/32), and hepatomegaly occurred 75% (24/32). In the febrile phase (day of illness 1-3), the mean white blood cell (WBC) counts were 7800 ± 800/mm(3) and platelets were 97,111 ± 37,826/mm(3). In the critical phase (day of illness 4-6), the mean WBC counts were 13,400 ± 2800/mm(3), and platelets were 30,100 ± 5749/mm(3). All mothers (100%) had laboratory-confirmed dengue by NS1 positive in the perinatal period. Conclusions The findings emphasize that early diagnosis of neonatal dengue should be based on a history of maternal illness, NS1 rapid test, and clinical presentation such as petechiae, hepatomegaly, and low platelet counts in the febrile phase. CI – Copyright © 2021. Published by Elsevier B.V.

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Link/DOI: 10.1016/j.jcv.2021.104758