A. J. M. Abo-Darub
Department of Biochemistry, Faculty of Medicine, Garyounis University, Benghazi, S.P.L.A.J.
Garyounis Medical Journal Vol. 2, No.1. January 1979:25-30
DNA repair activity was measured in peripheral blood lymphocytes from l8patierzts with Actinic Keratosis and 18 age-matched control subjects, by comparing the incorporation of [3H] -thymidine into cells after irradiation with ultra-violet light with that into unirradiated cells. The incorporation was followed autoradiographically or by measuring acid insoluble radio-activity in cells labelled in the presence of hydroxyurea. The repair activity in lymphocytes from Actinic keratosis patients was only 47.1% (±6.5%) of that in cells from the control subjects.
Keywords: DNA Repair Deficiency in Lymphocytes from Patients with Actinic Keratosis