Heikkinen I, Almangush A, Hagström J, Bello IO, Kauppila JH, Mäkinen LK, Haglund C, Nieminen P, Salo T, Leivo I.
Eur Arch Otorhinolaryngol. 2016 Nov;273(11):3905-3911. doi: 10.1007/s00405-016-3964-y. Epub 2016 Apr 18.
The proliferation marker, securin, is involved in the progression of many carcinomas. However, its expression in oral tongue squamous cell carcinoma (OTSCC) has not been previously studied. We examined securin expression by immunohistochemistry in OTSCC. A total of 93 cases treated for OTSCC were included in this study. Expression of securin in OTSCC was studied by immunohistochemistry of tissue microarrays (52 cases) and routine tumor sections (41 cases). Securin overexpression is significantly associated with higher tumor grade (P = 0.03). Overexpression of securin was observed more frequently in advanced stages of OTSCC than in earlier stages but the difference was not statistically significant. These findings suggest that overexpression of securin in OTSCC may be important during progression of this cancer. No significant association was found between securin expression and the prognosis of OTSCC.