Adam Elzagheid , Riyad Bendardaf, kari Syrjanen, Yrio Collan and Seppo Pyrhonen
1-Department of Pathology, University of Turku, Kiinamyllynkatu 10, FIN-20520, Turku, Finland.
2-Department of Oncology and Radiotherapy, Turku University Hospital.
JMJ Vol. 6, No. 2 (2006): 120-123
Objective: We aimed to assess whether E-cadherin expression has an association with the response to chemotherapy in colorectal cancer (CRC) patients. Material and Methods: The series consisted of 86 patients with locally advanced and metastatic CRC who received one of two chemotherapy regimes (either irinotecan alone, or irinotecan and 5-flurouracil with folinic acid). We examined immunohistochemically the E-cadherin expression in 86 formalin-fixed, paraffin-embedded primary tumours Results: The single most important finding was the significant association between the cytoplasmic E-cadherin index and response to treatment, in that lower levels of cytoplasmic E-cadherin expression was found to be significantly associated with higher response rate (p=0.017; Mann-Whitney). No such difference was found in the E-cadherin membrane index (p=0.458). Conclusions: This study suggests that cell adhesion molecules such as E-cadherin might be used to predict patient’s response to chemotherapy in advanced colorectal carcinoma. This may help in identifying patients who will benefit most from therapy for advanced colorectal cancer.
Keywords: E-cadherin, Colorectal cancer, Immunohistochemistry, Chemotherapy, Treatment response