Original article
English
Vinod K. Bhargava
Department of Pharmacology, Faculty of Medicine University of Garyounis, Benghazi, S.P.L.A.J.
Garyounis Medical Journal Vol. 6, No.1. January 1983:7-12
Abstract
In rats anaesthetised with Chioralose, auditory evoked responses were recorded from brainstem (FFP) and auditory cortex (CER). DFP or Paraoxon produced decrement and increment (biphasic) of the amplitudes of FFP. The increment effect was blocked by scopolamine, whereas decrement was antagonised by mecamylamine.
DFP and Paraoxon both increased the late components of CER. This effect was blocked by scopolamine. Nicotine failed to modify the evoked responses.
The present study suggest the presence of opposing muscarinic (excitatory) and nicotinic (inhibitory) cholinergic influences in the generation of FFP, while only muscarinics are involved in the generation of late components of CER.
Keywords: Effect of Disopropyl Phosphorofluoridate (DFP) and Paraoxon on Auditory Evoked Responses
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