Effect of Mixed Versus Unmixed Lidocaine with Propofol

Short communication


Faraj Traina ¹, Abduljalial Wafa ², Mohamed Traina ³, Emhamed Abujalala ³

1-Department of Anaesthesia, Misurata Central Hospital. 2-Department of Anaesthesia, Tripoli Central Hospital. 3-Department of Medicine, Misurata Central Hospital. Libya

JMJ 2009,Vol.9, No.2: 136-139


Propofol has a high incidence of pain with injection, particularly into small veins. Different techniques have been reported to alleviate the pain associated with propofol administration. Lidocaine is commonly used to decrease the pain on injection with propofol. This prospective study involved 60 patients aged from 14 to 75 years was designed and conducted to compare the effect of mixed and unmixed lidocaine with propofol in reducing pain on injection. Patients were randomly divided into two groups, according to lidocaine whether given as a pretreatment or a mixture. These two groups were subdivided according to the age and gender Group A [lidocaine, 20mg was given as a mixture with propofol](no = 30 patients), divided into subgroups (stratified random sampling). Group B [lidocaine, 20mg was given as a pretreatment](no=30patients), divided into subgroups (stratified random sampling). Our study indicated that lidocaine when given mixed with propofol was more effective in reducing the pain of injection than when it was given as a pretreatment [ p < 0.05 ]. In both methods, we found out that the pain was reduced in patients aged more than 45 years of age. It was statistically significant in group A p = 0.02 . Keywords: Propofol, Lidocaine, Complication, Anaesthesia, Libya. Link/DOI: http://www.jmj.org.ly/PDF/summer2009/136.pdf