Effects of the oil and mucilage from flaxseed (Linum usitatissimum) on gastric lesions induced by ethanol in rats

Original article


Dugani A 1, Auzzi A 2, Naas F 1, Megwez S 1

1-Department of Pharmacology and Clinical Pharmacy, 2-Department of Natural Products.Faculty of Pharmacy; Al-Fateh University for Medical Sciences, Tripoli, Libya

Libyan J Med AOP:080612


The anti-ulcer activity of the oil and mucilage obtained from flaxseed (Linum usitatissimum) was evaluated in a rat model of ethanol-induced gastric ulcer. Our results show that pretreatment of rats with flaxseed oil and flaxseed mucilage significantly reduced the number and length of gastric ulcers induced by ethanol. Flaxseed oil was more effective than flaxseed mucilage in reducing the number of ulcers. The reduction in ulcer severity (cumulative length in mm) provided by an oral dose of flaxseed oil (5 ml/kg) was more prominent than that obtained by ranitidine (50 mg/kg). This study indicates that both flaxseed oil and flaxseed mucilage can provide a cytoprotective effect against ethanol-induced gastric ulcers in rats.

Keywords: gastric ulcer, flaxseed, ethanol

Link/DOI: http://www.ljm.org.ly/articles/AOP/AOP080612/AOP080612.pdf