Original article
English
Shakeel F 1, Baboota S 2, Ahuja A 3, Ali J 4, Shafiq S 5.
1-Department of Pharmaceutics, Faculty of Pharmacy, Alarab Medical University, Benghazi, Libya. faiyazs@fastmail.fm 2-Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, (Hamdard University), New Delhi, India. 3-Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, (Hamdard University), New Delhi, India. 4-Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, (Hamdard University), New Delhi, India. 5-New Drug Delivery System (NDDS), Zydus Cadila Healthcare Ltd.
Pharmazie. 2009 Apr;64(4):258-9.
Abstract
The aim of the present study was to evaluate the enhanced anti-inflammatory effects of celecoxib (CXB) from a transdermally applied nanoemulsion. The anti-inflammatory effects of an optimized nanoemulsion formulation were compared with those of conventional CXB gel and nanoemulsion gel on carrageenan-induced paw edema in rats. These tests were compared using the Dunnett test of one-way analysis of variance (ANOVA). The % inhibition value after 24 h application was significant for optimized formulation C2 (85.4%) compared with CXB gel and nanoemulsion gel (p < 0.05). These results suggest that nanoemulsions can be successfully used to enhance the anti-inflammatory effects of CXB. Keywords: Enhanced anti-inflammatory effects of celecoxib from a transdermally applied nanoemulsion. Link/DOI: http://www.atypon-link.com/GVR/doi/abs/10.1691/ph.2009.8282