Original article
English
Wasan A.M.AlTai, Ibrahim M.Ateitalla, Sami A.M.AI Mudhaffar; Raad K.Muslih
Department of Biochemistry, Faculty of Medicine, Garyounis University, Benghazi, Libya
Garyounis Medical Journal Vol. 22, No.2. 2005:69-72
Abstract
Objectives: Evaluation of the activities of LDH, CK. and ALP in sera of gastric cancer and gastric ulcer patients. Methods: Lactate dehydrogenase (LDH), Creatine kinase (CK). and Alkaline phosphatase (ALP) were measured in sera of gastric cancer. gastric ulcer patients, and normal controls.
Results: A significant increase (P<0.00l) in the activity of LDH was found in sera of 30 gastric cancer patients as compared to 21 normal donors. In addition, A significant increase (P< 0.001) was found in serum LDH activities in 30 gastric cancer patients as compared to 16 gastric ulcer patients. Further, there were significant differences (P < 0.001) between sera of CK activities in 35 gastric cancer patients as compared to 25 normal donors. ALP activity showed no variations (0.5>P>0.2) in 31 gastric cancer patients when compared with 14 normal donors. Also, no significant differences (0.8>P>0.5) were observed on the serum ALP activities of 31 gastric cancer when compared to those of 15 gastric ulcer patients.
Conclusions: Serum LDH Levels may be introduced as biochemical markers in the diagnosis of gastric cancer and gastric ulcer. However. CK levels were elevated significantly in gastric cancer that could be as well of a diagnostic value.
Keywords: Gastric cancer. Lactate dehydrogenase. Creatine kinase. Alkaline phosphatase
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