Evaluation of Total Sialic Acid and Carbohydrate antigen 15-3 in Gastric Cancer Patients

Original article


Wasan A.M. AlTai, Ibrahim M.Ateitalla, Sami A.M.AI Mudhaffar, Raad K.Muslih

Department of Biochemistry, Faculty of Medicine, Garyounis University, Benghazi, Libya

Garyounis Medical Journal Vol. 22, No.2. 2005:33-36


Method and Results: Total Sialic acid (TSA) levels were increased significantly (P<0.00l 1 in sera of 28 gastric cancer patients compared to 29 normal donors. In addition, a significant increase in TSA levels was found in sera obtained from 28 gastric cancer patients compared to those of stomach tissue extracts of 17 gastric cancer patients. Carbohydrate antigen 15-3 (CA 15-3) levels in sera of gastric cancer were measured by lmmmunoradiometric assay (IRMA), It was found that CA 15-3 levels were increased significantly (P < 0.001) in 13 patients with gastric cancer compared to those of 12 normal donors. Conclusion: Total Sialic Acid (TSA and CA 15-3 levels are elevated in sera of gastric cancer patients. Therefore, they are useful as diagnostic markers for gastric cancer. Keywords: Gastric cancer. Total Sialic Acid. Carbohydrate Antigen 15-3 (CA 15-3) Link/DOI: