Evidence of the Potential of Nuclear Morphometry and DNA Cytometry in Fine Needle Aspiration Biopsies of the Breast

Review

English

Adam Elzagheid┬╣, Yrjo Collan ┬▓

1-Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1 PB 52, FIN-20521, Turku, Finland 2-Department of Pathology, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, FIN-20520, Turku, Finland

JMJ Vol.8 No.1 (Spring) 2008:10-14

Abstract

Quantitation of nuclear DNA content by cytometry and measurement of nuclear size by morphometry can be used as an adjuncts to diagnosis and grading of malignant tumours, also in association of fine needle aspiration biopsy (FNAD). DNA cytometry, and nuclear morphometry could be helpful in confirming the impression of the cytologist and in giving further value to FNAB diagnosis. In this review article, we have tried to outline the potential of DNA cytometry and nuclear morphometry in distinguishing between breast lesions. We also discuss the methodology, and stress the value of DNA cytometry and nuclear morphometry in the prognosis of breast cancer. There is a lot of research potential in DNA cytometry and nuclear morphometry, such research could be very helpful for the cytologist and the pathologist alike.

Keywords: Breast, DNA cytometry, Morphometry, Fine Needle Aspiration Biopsy (FNAB)

Link/DOI: http://www.jmj.org.ly/modules.php?name=News&file=article&sid=1444