Fibrodysplasia Ossificans Progressive and its Association with primary amenorrhea

Case report


M.S. Elsaiti MD, S.E. Gerryo MD, FRCP

Department of Medicine and Endocrinology,
Jamahiriya Hospital, Benghazi, Libya

JMJ Vol. 1, No. 2 (November 2001): 77-78


Fibrodysplasia ossificans progressive (fop) is a rare autosomal dominant disease characterized by progressive ossification of striated muscles. Secondary amenorrhea is described as an uncommon feature. This case report described a 24- years old female patient with FOP and primary amenorrhea who failed to have withdrawal bleeding after two courses of estrogen-progesterone challenge therapy in spite of normal pituitary ovarian function. To clarify possible explanation for the association between FOP and primary amenorrhea further studies are needed.

Keywords: primary amenorrhea, Fibrodysplasia Ossification