Fixed Drug Eruption to Metformin Hydrochloride

Case report

English

Gamal Ahmed Duweb¹, Ghada Abdulla Tayeb ²

1-Department of Dermatology, Garyounis university, Benghazi-Libya. 2-Dermatology department, Jamahiriya hospital.Benghazi-Libya

JMJ Vo1.7 No.1 (Spring) 2007:69-70

Abstract

A 55 year-old male is a known patient of diabetes mellitus on oral hypoglycaemic drug for the last 12 years. Recently because of poor control of his high blood sugar, his physician added another oral hypoglycaemic drug- Metformin hydrochloride 500 mg single dose. The patient developed itching and bollous lesions over the extremities and genitalia with dusky red colour surrounding the bullae with erosions in the glans penis and the prepuce. The patient had the same type of lesions in 1988 and 1995 due to aspirin where the lesions healed with marked hyperpigmentaion. We report the first case of fixed drug eruption to metformin hydrochloride to be reported in literature and the possibility of cross sensitivity with aspirin.

Keywords: Fixed drug eruption, Metformin hydrochloride, Hyperpigmentaion

Link/DOI: http://www.jmj.org.ly/modules.php?name=News&file=article&sid=1381