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Subramaniam S, Mohapatra JK, Das B, Sanyal A, Pattnaik B.
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Infect Genet Evol. 2015 Mar;30:59-64. doi: 10.1016/j.meegid.2014.12.009. Epub 2014 Dec 13.
Abstract
In recent times, majority of the foot-and-mouth disease (FMD) outbreaks in India are caused by serotype O Ind2001 lineage. The lineage has diverged into four sub-lineages (Ind2001a, b, c and d). We report here the genetic and antigenic analyses of nine Ind2001d isolates that caused outbreaks during April 2013-March 2014 in India. The length of the genomes of outbreak viruses varied between 8153 and 8181 nucleotides without any insertion or deletion in the coding region. Of the nine isolates analyzed antigenically against the currently used Indian vaccine strain INDR2/1975, eight showed good cross serological match (>0.3) indicating optimal antigenic coverage by the vaccine strain. An unprecedented deletion of 22 nucleotides between position 57 and 78 was observed in the 3′ untranslated region of one of the isolates without compromising the virus viability, which imply that partial distortion in SL2 of 3’UTR may not have influence on virus viability at least under in-vitro conditions. Recently the Ind2001 lineage has been reported from several countries including Libya and spread of this lineage across a wide geographical area needs to be monitored carefully to avoid any future pandemic. CI – Copyright © 2014 Elsevier B.V. All rights reserved.
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Link/DOI: 10.1016/j.meegid.2014.12.009