Original article
English
Khalidah R Al-Sarraj, Saleh S. Mofteh, Salha Zoubi
Department of anatomy and histology, Faculty of Medicine, Garyounis University Benghazi, Libya
Garyounis Medical Journal Vol. 21, No.1. 2004:28-34
Abstract
Objectives non-steroid anti-inflammatory drugs such as ibuprofen has been in wide spread use as anti-inflammatory & analgesics for more than 30 years and has been introduced as over the counter drug in many countries. In recent years there has been an increasing number of reports of various types ofrenal diseases that are associated with long-term therapeutic doses of ibuprofen. Not much work has been done on the histological changes accompanying the use of ibuprofen in animals. Thus the aim of this work is to study the histological changes in rat kidney after administration of therapeutic & overdoses of ibuprofen orally. Material & Methods: eighty four male albino rats were used & divided into four groups, one used as control group, one received therapeutic dose of ibuprofen daily, one received overdose and the last group was left for recovery. Paraffin, routine stain, special stains & histochemical technique were used in this study. Results: the results indicate that 1. Long treatment of therapeutic doses& short treatment of overdoses of ibuprofen showed variable degrees of histological changes predominantly within the interstitial tissue ranging from marked interstitial cellular infiltrates to focal degenerative fibrotic areas. 2. Increased deposition of collagen fibers was detected around many renal tubules, renal corpuscles and renal Arterioles. 3. Changes in tubular and glomerular basement membrane were also detected. 4.Discontinuation of the drug does not lead to complete recovery. Conclusion: ibuprofen when taken in overdoses or taken in therapeutic doses for long time causes variable degrees of renal injuries and the recovery was incomplete after discontinuation of the drug.
Keywords: Histological Study Of The Effect Of Ibuprofen On Rat Kidney
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