HLA-A, -B and -DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations



Galgani A, Mancino G, Martínez-Labarga C, Cicconi R, Mattei M, Amicosante M, Bonanno CT, Di Sano C, Gimil GS, Salerno A, Colizzi V, Montesano C.


Hum Immunol. 2013 Jan;74(1):52-9. doi: 10.1016/j.humimm.2012.10.001. Epub 2012 Oct 16.


The frequencies of HLA-A, HLA-B and HLA-DRB1 alleles in 118 unrelated Libyans from
Benghazi (Cyrenaica) were analysed using high resolution typing and compared with
other populations. Their relatedness has been tested by correspondence analyses and
principal component analysis. The most frequent HLA-A alleles were A(∗)02:01:01:01
(15.7%), A(∗)01:01:01:01 (11.4%) and A(∗)03:01:01:01 (9.3%). For the HLA-B locus,
the commonest allele was HLA-B(∗)50:01:01 (14.4%) followed by B(∗)51:01:01 (9.8%)
and B(∗)08:01:01 (6.4%). For the HLA-DRB1 locus, the commonest was
HLA-DRB1(∗)07:01:01:01 (16.9%) followed by DRB1(∗)03:01:01:01 (13.6%) and
DRB1(∗)13:02:01 (9.3%). The most frequent two-locus haplotypes were
HLA-A(∗)02:01:01:01-B(∗)07:02:01 (3.0%) and HLA-B(∗)50:01:01-DRB1(∗)07:01:01:01
(9.6%), and three-locus haplotypes were
HLA-A(∗)02:01:01:01-B(∗)50:01:01-DRB1(∗)07:01:01:01 (4.2%) and
HLA-A(∗)11:01:01-B(∗)52:01:01:01-DRB1(∗)15:02:01 (2.5%). This study is the first on
the HLA status of a Libyan population. The results, when compared to similar HLA
data obtained previously from African and Mediterranean populations, indicate
genetic influences from several ethnic groups. Moreover, the differences in the HLA
allele frequencies between the Libyan population and others reveals that significant
admixture has occurred between the original Berber inhabitants and neighbouring and
more distant populations, even though a strong genetic Berber substratum remains.
These data will be of value to future anthropological and disease association
studies involving the Libyan population.

Keywords: .

Link/DOI: 10.1016/j.humimm.2012.10.001