Human bone marrow-derived mesenchymal stem cells



Nasef A 1, Fouillard L 1, El-Taguri A 2 , Lopez M 1

1-EA 1638 –Hématologie, Faculté de Médicine Saint-Antoine, Université de Pierre et Marie Curie, Paris VI, 27 Rue de Chaligny, 75012 Paris, France; 2-Hopital Enfants Malades Necker, Paris, France.

Libyan J Med AOP: 070705 (published 07 September 2007)


Mesenchymal stem cells (MSCs) have elicited a great clinical interest, particularly in the areas of regenerative medicine and induction of tolerance in allogeneic transplantation. Previous reports demonstrated the feasibility of transplanting MSCs, which generates new prospects in cellular therapy. Recently, injection of MSCs induced remission of steroid-resistant acute graft-versus-host disease (GVHD). This review summarizes the knowledge and possible future clinical uses of MSCs.

Keywords: mesenchymal stem cells, plasticity, immunomodulation, cancer, gene therapy.