Hypotension during Spinal Anesthesia: Bupivacaine Versus Bupivacaine-Fentanyl Intrathecal Injection

Original article


Masoud Ali Lfeituri, Jaber Rashid EL Madani

Department of Surgery, Unit of Anaesthesia and IntensiveCare, Faculty of Medicine, Garyourns University, Benghazi, Libya.

Garyounis Medical Journal Vol. 21, No.2. 2004:15-19


Forty adult patients of two groups scheduled for surgical procedures involving the lower part of the body were enrolled in a study comparing the incidence and severity of hypotension during the first two hours of spinal anesthesia (SA). SA was induced either by 15mg of 0.5% hyperbaric bupivacaine (B group, 20 patients) or 0.5% hyperbaric bupivacaine (10mg) + 25 microgram fentanyl (FB group, 20 patients). Systolic (SBP), diastolic (DBP) and mean (MAP) arterial blood pressures were significantly lower in group B than in group FB. In group B, the lowest percentages of SBP, DBP and MAP pressure were 79%, 80% and 79% respectively, versus 87%, 8% and 8% for group FB. 70% of patients in group B and 40% in group FB developed hypotension. Total doses of ephedrine therapy were significantly higher in group B (30.4 mg ± 24.5) than group FB (12.6 mg ± 17.4).

Keywords: Bupivacaine- intrathecal fentanyl – hypotension