D. B. Konar, R. C. Jain
1-Department of Physiology, Faculty of Medicine, University of Garyounis, Benghazi. 2- Department of Pathology, Faculty of Medicine, University of Garyounis, Benghazi.
Garyounis Medical Journal Vol. 1, No.1. January 1978:17-19
The hypotensive activity of the aqueous extract of garlic was assessed in normal, atropinized, and ganglion-blocked rats. At lower doses, intravenous injection of the test material in control animals produced a significant fall in the arterial blood pressure. The amplitude and the duration of the response were dependent on the dose of the test material. In atropinized animals, the same doses produced a moderate rise in the B.P.; whereas in ganglion-blocked animals, there was no significant change. At higher doses, however, there was a marked fall in B.P. in all the groups. These preliminary observations show the existence of a hypotensive agent in the aqueous extract of garlic which behaved as an acetylcholine-like substance in lower doses. Marked hypotensive activity at higher doses could be due to the presence of an additional agent acting directly on the myocardium.
Keywords: Hypotensive Action of Garlic