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Dey B, Katakam P, Assaleh FH, Chandu BR, Adiki SK, Mitra A.
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J Pharm Anal. 2015 Dec;5(6):389-395. doi: 10.1016/j.jpha.2015.02.003. Epub 2015 Mar 10.
Abstract
Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies (IVIVC) has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins, calcium and milk. Appreciable IVIVC results proved that dissolution studies could serve as an alternative to in vivo bioavailability and also support bio-waivers.
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Link/DOI: 10.1016/j.jpha.2015.02.003