Inducible Clindamycin Resistance among Staphylococci Isolated from Burn Patients

Original article


Zorgani A1,2, Shawerf O1, Tawil K1, El-Turki E1, Ghenghesh KS1

1-Department of Microbiology and Immunology, Faculty of Medicine, El-Fateh University for Medical Sciences. 2-Tripoli Burn Center, Tripoli-Libya

Libyan J Med 2009; 4(3):D149-152


Clindamycin has been used successfully to treat pneumonia and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. However, inducible clindamycin resistance has been described as a cause of treatment failure of such infections. A total of 159 staphylococcal isolates from different clinical specimens from burn patients in Tripoli Burn Center were tested for inducible clindamycin resistance by the disk-diffusion induction test. Inducible clindamycin resistance was detected in 66.2% of 65 methicillin-resistant S. aureus isolates and in none of 55 methicillin-sensitive S. aureus, 10 methicillin-resistant coagulase negative staphylococci and 29 methicllin-sensitive
coagulase negative staphylococci isolates. In our setting, clindamycin can be used for the treatment of infections due to staphylococci, but we recommend that staphylococci isolates, particularly methicillin-resistant S. aureus, are tested by the D-test before treatment.

Keywords: Inducible clindamycin resistance, Staphylococci, Burn patients, Libya