Letter
English
Tarik Sqalli Houssaïni 1, Asmaâ Laboudi 2, Hakima Rhou 2, Fatima Ezzaïtoun 2, Loubna Benamar 2, Naïma Ouzeddoun 2, Rabea Bayahia 2
1-Nephrology department Ibn Sina University Hospital Rabat, Morocco Email: tariksqalli@hotmail.com 2-Nephrology department Ibn Sina University Hospital Rabat, Morocco
Libyan J Med 2010, 5: 5334 – DOI: 10.3402/ljm.v5i0.5334
Abstract
Ticlopidine is an effective anti-platelet agent used for prevention of thrombosis. It was reported that treatment with ticlopidine at the dose of 250 mg daily in kidney transplant patients caused significant reduction of cyclosporin A (CsA) blood levels. In heart transplant patients treated with higher doses of ticlopidine 500 mg daily, it was found to cause significant decrease of cyclosporin concentration but not in those treated with only 250 mg daily. It was thought that ticlopidine interacts with cyclosporin metabolism at cytochrome P450.
Keywords: Is the interaction between ticlopidine and cyclosporin dose related? Report of three cases
Link/DOI: http://www.libyanjournalofmedicine.net/index.php/ljm/article/view/5334/html_13