Kaposi’s Sarcoma: Two brothers after renal transplantation

Case report


El-Zurghany A*, Benghazi M*, Osman E**, Duwed G***

*Dermatology Department, ** Medical Department, Faculty of Medicine, Elfateh University, Tripoli, Libya ***Dermatology Department, Faculty of Medicine, AL-Tahaddi University, Sirt, Libya

JMJ Vol. 2, No. 2 (September 2002): 77-81


Kaposi’s Sarcoma (KS) is a polymorphous, angioporoliferative cutaneous or visceral disease, which is not clear even today whether is an inflammatory condition or true neoplasia. KS associated with non – HIV induced immunosuppression such as transplant patients, is a well-recognized clinical subset. We present two brothers aged 20 years and 18years with the diagnosis of end-stage renal failure on haemodialysis for 5 years and 2 years respectively. Renal transplantation from non-related donors was performed for both of them. Both received the triple immunosuppression protocol (Prednisolone 0.75 mg/kg/day, Cyclosporine A 7mg/kg/day and azatthioprine 1.5 mg/kg/day). Both patients developed violaceous nodular lesions on the hands and trunk, which disseminated all over the body with systemic involvement including lungs, bones and lymph nodes. Histology of the cutaneous lesion in both patients confirmed the diagnosis of KS. Chemotherapy regimen (Adriamycin, Bleomycin, and Vinblastine) was initiated in collaborated with Oncology Department and in spite of that, the progression of the disease was aggressive and both patients died within 6 months after the diagnosis.

Keywords: Kaposi’s sarcoma (KS), Immunosuppression

Link/DOI: http://www.jmj.org.ly/modules.php?name=News&file=article&sid=1247