Low Dose “Physiological Insulin”: Treatment of Severe Diabetic Ketoacidosis

Original article


Baligh-Ur-Rehman, Rifat Naghmi, Omar Mahmoud Elmargani

Diabetes Hospital and Department of Medicine, Faculty of Medicine, Al Fateh University, Tripoli, The Socialist People’s Libyan Arab Jamahiriya.

Al Fateh Med J Vol .2, No. 1. July 1982:45-50.


In 1981, 65% of patients admitted in the Diabetic Centre, Tripoli, had diabetic ketoacidosis (Ferric chloride+). To assess the effect of “Physiological insulin”, small dose intramuscular method, 37 cases of severe diabetic ketoacidoses were treated with this method. The plasma glucose declined in 7.6 ±5.5 hours and ketosis was controlled in 8.6±1.18 hours. Ketonaemia completely cleared up in 12.8± 6.34 hours. Alkali (bicarbonate) was administered to a special case of diabetic ketoacidosis combined with lactic acidosis. There was one case each of hypoglycaemia and hypokalaemia. Insulin resistance was encountered in one case of nonketotic hyperosmolar, (rather unusual) with renal failure.
Small dose, intermittent intramuscular method is simple, adequate and effective, particularly in developing countries, where medical, nursing and laboratory facilities are available in specialised centres only.

Keywords: Low Dose “Physiological Insulin”: Treatment of Severe Diabetic Ketoacidosis