Essa M. Abdulla 1, S. A. M. A. Hussein 2
1-Department of Microbiology, Faculty of Medicine, University of Garyounis, Benghazi, S.P.L.A.J. 2-Department of Pediatrics, Faculty of Medicine, University of Garyounis, Benghazi, S.P.L.A.J.
Garyounis Medical Journal Vol. 1, No.2. July 1978:9-13
Immunoglobulins A, G and M were measured in the saliva of 35 children with bronchial asthma and their families involving a total of 123 individuals by means of radial immunodiffusion using monospecific antisera and the values compared with that of salivas from 31 control subjects. The following mean values were obtained:for control subjects, IgA was 9.6 mg/100 ml, IgG was 6.04 mg/100 ml, and 1gM was 1.88 mg/100 ml; for patients with allergic asthma, IgA was 6.18 mg/100 ml, IgG was 1.12 mg/100 ml, and 1gM was 2.0 mg/100 ml of saliva. While IgG and 1gM values in both control and sick groups were approximately similar, IgA levels in 23 of 35 children and 12 of 17 parents with asthma were found to be significantly lower than normal to a degree ranging from 29.1% in certain children to 51.5% in adults. Evidence is also presented that IgA deficiency in children appears to be an inherited tendency.
Keywords: Lowered Salivary IgA Levels in Children with Allergic Asthma and a Familial Tendency