Modification by muscimol of naloxone-precipitated withdrawal symptoms in morphine-dependent mice.

Original article


El-Kadi AO, Sharif SI.

Department of Pharmacology, Al-Arab Medical University, Benghazi, Libya.

Gen Pharmacol. 1995 Nov;26(7):1579-81.


1. In morphine-dependent mice, muscimol, a GABAA agonist when given i.p. 30 min before naloxone, attenuated the naloxone-precipitated withdrawal symptoms of jumping, “wet dog” shakes and burrowing, but not body weight loss. 2. Muscimol produced a hypothermic effect which was further aggravated by naloxone.

Keywords: Mice; morphine; muscimol; naloxone; withdrawal symptoms