Original article
English
El-Kadi AO, Sharif SI.
Department of Pharmacology, Al-Arab Medical University, Benghazi, Libya.
Gen Pharmacol. 1995 Nov;26(7):1579-81.
Abstract
1. In morphine-dependent mice, muscimol, a GABAA agonist when given i.p. 30 min before naloxone, attenuated the naloxone-precipitated withdrawal symptoms of jumping, “wet dog” shakes and burrowing, but not body weight loss. 2. Muscimol produced a hypothermic effect which was further aggravated by naloxone.
Keywords: Mice; morphine; muscimol; naloxone; withdrawal symptoms
Link/DOI: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T71-3XRP8DC-P&_user=10&_coverDate=11%2F30%2F1995&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=1eb1f88bb87fac470d827e00c81b25c9