Perylenequinones from an endophytic Alternaria sp. of Pinus ponderosa



Tantry MA, Idris AS, Williamson JS, Shafi T, Dar JS, Malik TA, Ganai BA, Shawl AS.


Heliyon. 2018 Dec 19;4(12):e01046. doi: 10.1016/j.heliyon.2018.e01046. 2018 Dec.


The differential solvent extraction and further purification of fractions of endophytic Alternaria sp. isolated from Pinus ponderosa led to the isolation of further two perylenequinone compounds as 3,6,6a,9,10-pentahydroxy-7,8-epoxy-4-oxo-4,5,6,6a,6b,7,8,9-octahydroperylene (1) and 3,6,6a,7,10-pentahydroxy-4,9-dioxo-4,5,6,6a,6b,7,8,9-octahydroperylene (2). Structure of compounds 1-2 was determined on the basis of detailed spectroscopic analysis, as well as by comparison with literature reports. The antimicrobial, antileismanial, antimalarial and cytotoxic activities of compound 1 and 2 were evaluated.

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Link/DOI: 10.1016/j.heliyon.2018.e01046