Original article
English
Elhwuegi AS.
Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Al-Fateh Medical University, Tripoli, Libya.
Pharmacology. 1994 Nov;49(5):308-13.
Abstract
The hypnosis and hypothermia induced by phenobarbitone (100 mg/kg i.p.) were greatly potentiated by combined treatment with alpha-methylparatyrosine (alpha-MPT, 250 mg/kg i.p.). alpha-MPT per se produced sedation and hypothermia. Measurement of blood and brain levels of phenobarbitone in rats treated with phenobarbitone alone or phenobarbitone plus alpha-MPT revealed that the latter delayed the disappearance rates of phenobarbitone from both brain and plasma. These results suggest an interaction at the site of distribution, metabolism and/or excretion of phenobarbitone. The possibility of a pharmacodynamic interaction involving neurotransmitters is also discussed.
Keywords: Pharmacodynamic and pharmacokinetic interactions between alpha-methylparatyrosine and phenobarbitone.
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