Original article
English
Tariq Umer Qazi
Faculty of Pharmacy, Al Fateh University, Tripoli, S.P.L.A.J.
Al Fateh Med. J Vol .1, No. 1. January 1981:17-20
Abstract
A novel dimethoxy tricyclic compound TI (ethyl 6,7,8,9- tetrahydro- 2,3-dimet- hoxy-9,IO- dioxo-5,8- methano-5H- benzocycloheptene-5- carboxylate) and a similar monomethoxy compound T2 its derivative T3 (hemi acetal) (1), have been pharmacologically evaluated. It appears that these compounds have nearly similar dimensions as that of stilboestrol (2). During a routine pharmacological screening it was found that T1, T2 and T3 exhibited a marked ability to potentiate stilboestrol at a dose level which had no intrinsic oestrogenic activity.
Keywords: Pharmacological Evaluation of Three Novel Tricylic Compounds for Their Oestrogen Potentiating Properties
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