Original article
English
A.A. AbdelGayoum 1, B.H. Ali 2, K.M. Ghwarsha 1, A.A. Bashir 2
1-Department of Biochemistry, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya. 2- Department of Pharmacology, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya.
Sebha Med J. 1998;Vol.1(2):126-129
Abstract
Rats were treated orally with Furazolidone at doses of 50, 100 or 200 mg/kg of body wt. for three consecutive days. The drug increased, dose-dependently, the fasting plasma cholesterol and triacyiglycerol concentrations, whereas, the plasma cholesterol and phospholipid concentrations were significantly raised by the 200 mg/kg dose. However, the post-heparin; plasma lipase activity was decreased in a dose-dependent manner by the drug.
On the other hand, the hepatic cholesterol content was not significantly affected by any of the doses used, whereas, the hepatic triacylglycerol content was significantly (p<0.05) increased by the Furazolidone at doses of 100 and 200 mg/kg dose of the drug, but unaffected by the lower doses. Fatty infiltration was observed in the livers of animals treated with the 100 and 200 mg/kg doses of the drug.
Keywords: Plasma And Hepatic Lipid Content of Furazolidone Treated Rats
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