Plasma Lipid Profile in Type 2 Diabetes Mellitus With and Without Ischaemic Heart Disease

Original article


Issa Ibrahim Gargum┬╣, Salah Bugrain┬▓ and Abdul Hamid K. Albargathy┬▓

1-Faculty of Medicine 2-Faculty of Science. Garyounis University, Benghazi, Libya

JMJ 2007,Vol.7, No.4: 254-260


The concentration of plasma lipids and lipoproteins in type 2 diabetes mellitus with and without ischaemic heart disease were studied. The subjects of this study were divided into three groups. Group 1 includes those diabetics with ischaemic heart disease, group 2 includes those diabetics without IHD and group 3 includes healthy volunteers (control). Each group was divided into males and females. Both diabetic groups (1 and 2) were again divided according to current treatment (oral hypoglycaemic agents versus insulin therapy). Plasma total cholesterol, high density lipoproteins ( HDL-C ), low density lipoproteins ( LDL-C ) , very low density lipoproteins ( VLDL-C ) and triglycerides levels were determined after 10 hours – fasting. Group-1showed significantly high concentration of total, LDL, VLDL cholesterols and triglycerides with low level of HDL-C compared with group 2 and group 3. Apart from significantly low HDL-C all studied parameters of group 2 showed significantly high concentration compared to group 3 .Regarding the type of treatment, group 1 and group 2 showed significantly higher levels of triglycerides and VLDL-C in patients treated orally than in those treated with insulin. The difference in levels of total, LDL and HDL cholesterol was not significant. Gender does not showed any significant difference in group 1 and group 3 whereas group 2 showed significant high levels of triglycerides and VLDL-C in females

Keywords: Lipids, lipoprotein, Diabetes Mellitus Type 2, Ischemic Heart Disease.