Department of Medicine, Faculty of Medicine, University of Garyounis, Benghazi, S.P.L.A.J.
Garyounis Medical Journal Vol. 4, No.1. January 1981:45-48
In the 5 year period between 1975 to 1979,34 patients with rheumatic valvular lesions received mechanical aortic valve prosthesis and 45 patients received mechanical mitral valve prosthesis. Post operatively these patients were put on long term anti-coagulant therapy. Out of a total of 79 patients, 15 patients developed cerebral infarction, which proved fatal in 3 patients. 16 patients developed clinically detectable pulmonary embolism, which proved fatal in 4 of them. Contrary to the experience of others, an overall incidence of 39 percent of major thrombo-embolic episodes (31 out of 79) is disturbingly high. Besides many minor cerebral and pulmonary embolic episodes might have gone undetected or unreported. A review of problems and analysis of various factors along with certain suggestions to minimize the morbidity and mortality is presented in this article.
Keywords: Problems of Long Term Anticoagulant Therapy in Libyan Patients with Mechanical Prosthetic Valves