Sister chromatid exchange analysis in monitoring chlorambucil therapy in primary nephrotic syndrome of childhood.

Short communication


Elzouki AY 1, al-Nassar K 1, al-Ali M 1, Malik G 2, Elsharie F 2, Jaiswal OP 2.

1-Department of Paediatrics, Faculty of Medicine, Kuwait University. 2-Faculty of Medicine, ALArab Medical University, Benghazi, Libya

Pediatr Nephrol. 1991 Jan;5(1):59-61.


Sister chromatid exchange (SCE) analysis is the most sensitive method for assessing chromosome damage induced by chemical mutagens. We report the SCE of peripheral blood lymphocytes in children with primary nephrotic syndrome (NS) treated with chlorambucil. Group I consisted of 20 normal children, group 2 of 14 children with primary NS who had never received a cytotoxic drug and group III of 7 children with primary NS who had received chlorambucil, which was discontinued 6-36 months prior to the study. Group IV consisted of 4 nephrotic children who were receiving chlorambucil therapy during the study. There was no significant increase in SCE in group III compared with group I or group II (P much greater than 0.05). A significant rise in SCE (P less than 0.05) was seen in all patients in group IV.

Keywords: Chlorambucil – Nephrotic syndrome – Malignancy – Leukaemia