Skeletal re-mineralization after surgery for primary and secondary hyperparathyroidism

Original article


S Abugassa, J Nordenstrom, S Eriksson, G Mollerstrom, A. Alveryd

Huddinge, Sweden

JMJ Vol. 2, No. 2 (September 2002): 71-75


Bone mineral was measured by photon adsorptiometry before and after parathyroid surgery in patients with primary or secondary hyperparathyroidism (HPT). The mean bone mineral density of lumber vertebrae was 0.82 ± 0.04 (SEM) gm/cm2 in primary HPT (n=7) and 0.86 ± 0.05 gm/cm2. In secondary HPT (n=11.) These values are significantly lower than for age-matched normal subject. After successful parathyroid surgery, the bone mass of the distal radius and lumber vertebrae increased by approximately 10% within 3 months after operation and then remained stable during the first postoperative year. In conclusion, parathyroid surgery is followed by a significant increase of bone mass in primary and secondary HPT. The substantial increase in bone mass in parts of the skeleton consisting predominantly of trabecular, bone, as well as in sites with predominantly cortical bone, indicates that re-mineralization after operation involves a generalized increase in bone mass.

Keywords: Bone mineral, Photon adsorptiometry, Hyperparathyroidism (HPT)