Department of Laboratory Medicine. Faculty of Medicine. Al Arab Medical University, Benghazi, S.P.L.A.J.
Garyounis Medical Journal Vol. 14, No. 1-2. January/July 1991:.22-26
Organophosphates are powerful, widely used pesticides which disrupt normal cholinergic neural impulse transmission of the central and peripheral nervous system in vertebrates by inhibiting AChE. Effect of three graded doses of Dichlorvos (3.0, 1.5, 0.75 mg/kg b.w., i.p. daily for 7 days) was evaluated on acetylcholinesterase activity of rat brain and spinal cord, A dose response curve was obtained and it was observed that the spinal cord was the most susceptible region, Administration of pyridine -2- aldoxime, considerably reactivated the enzyme acerylcholinesterase. Variation in the reactivation of enzyme in the discrete regions of rat NS suggests that individual regions behave as disparate organs and the extent of toxicity depends both on the region and the dose of Dichlorvos administered.
Keywords: Studies on the Effect of Dichlorvos and 2 PAM on Rat Brain Acetyicholinesterase