M. M. Ziu
Department of Biochemistry, Faculty of Medicine, University of Garyounis, Benghazi, S.P.L.A.J
Garyounis Medical Journal Vol. 4, No.2. July 1981:37-44
Several key actions of androgen on the prostate can now be accounted for as sequalae of the association of dihydrotestosterone with cystosatic receptor. This complex serves as inhibitor of translation and regulator of gene replication and transcription. Far less clear is how epithelial height, metabolic rate, secretion and uptake of precursors and ions is controlled. While some think these consequences of new protein synthesis, a more plausible explanation is that these separate processes are energized by a rise in available androgen. Active transport is coupled to mitochrondrial energy production to more materials into the cell and support biosynthesis of uridine is significantly increased by the presence of 1O—7M testosterone in vitro. While there is no RNA synthesis, there is a dose-related enrichment of the pools of nucleotides. This increased ion transport (uptake), is independent of nuclear and new protein mediation. The rate-limiting step is uptake, not nucleotide phospho,ylation, and these phenomena may be related to the action of steroid on the /3 protein androgen receptor of the plasma membrane.
Keywords: Testosterone Effect on Uptake and Metabolism of Uridine by Human Prostate in Vitro