The Effect of Aspirin and Dipyridamole Therapy in Haemolytic Uraemic Syndrome

Original article


M. El Mauhoub 1, G. Sudarshan 2, R. Baloch 2

1-Department of Paediatrics, Faculty of Medicine, University of Garyounis, Benghazi,S.P.L.A.J. 2-El Fatah Children Hospital, Benghazi, S.P.L.A .J.

Garyounis Medical Journal Vol. 7, No. 1. January 1984:.31-37


The hemolytic uremic syndrome (HUS) is variable in its clinical manifestations and consists mainly of thrombocytopaenia, schistocytosis and acute renal failure (17). Currently its aetiology is unknown. It is generally preceeded by either diarrhoeal illness or a slight infection of the upper respiratory tract. Two major components underly the pathogenesis of the lesion: small vessel endothelial cell breakdown and haemostatic activation. The outcome of each clinical episode depends, therefore, at least in part, on the extent of endothelial injury and on the degree of platelet-fibrin response. It is predominantly a disease of infancy, although it does occur in older children and adults. Chronic renal failure, hypertension and neurological sequelae are some of its late consequences. This disease accounts for relatively low mortality figures. An effective mode of therapy to stop the primary pathogenic process is not yet available, so supporting measures such as peritoneal dialysis, blood transfusions and fluid restriction until the return of the renal function is the mainstay of therapy. Several modes of drug therapy, like anticoagulants (20), anti-platelets agents (2,23), corticosteroids (28), streptokinase (24,30) and even plasma exchange (27) were tried. We had an opportunity to manage 3 cases of HUS in the children s Hospital, Ben ghazi in 1982. These cases were treated with anti-platelet (2,23) that is, aspirin and dipyridamole of longer duration previously tried. They have responded to this therapy well and rare being followed up. We are presenting these three cases herewith.

Keywords: The Effect of Aspirin and Dipyridamole Therapy in Haemolytic Uraemic Syndrome