Mohammad Tosif Khan
Department of Pharmacology, Faculty of Medicine, University of Garyounis, Benghazi, S.P.L.A.J.
Garyounis Medical Journal Vol. 2, No.2. July 1979: 49-53
The daily administration of diphenylhydantoin (100 mg/hg, I.P) to rats for 9 days significantly increased the liver weight as compared to control animals. The increment in hepatic tissue was also observed in partially hepatectomized rats which received the drug pre or post operatively. At necropsy a greater adhesive reaction was found around the area of surgery in drug treated rats. This reaction was absent in control rats or in drug treated rats which were sacrificed after 9 days. This adhesive reaction may be stimulation of fibroblastic proliferation around the area of surgery. Diphenylhydantoin had no effect on liver water content. Histological examination of liver section did not show any difference between drug treated and control rats. Results of present study indicate that diphenylhydantoin had a stimulatory effect on the cells of non-connective tissue origin. Furthermore this drug had a stimulatory effect on liver growth in normal as well as hepatectomized rats.
Keywords: The Effect of Diphenylhydantoin on Liver Regeneration in Partially Hepatectomized and on Liver Growth in Normal Rats