B.H.Ali , A.A. AbdelGayoum
Garyounis Medical Journal Vol. 18. 1995-1997: 79-83
The antischistosomal drug oltipraz was administered to mice in single oral doses of 25,125,625 mg/kg. And the animal killed 24 hrs thereafter. Clinical, haematological and pathological investigations indicated that doses of 25 or 125 mg/kg produced no overt signs of toxicity in the seated mice. At a dose of 625 mg/kg, the drug produced slight decreases in haemoglobin concentration, haematocrit and erythrocyte counts. Histopathologically it caused changes in live md lung. These consisted of pulmonary interstitial oedema and atelectasis, and in the liver, of congestion, multifocal necrosis, dilatation of central veins and diffuse hepatocellular cloudy swelling. In another experiment. Oltipraz (625mg/kg) was given to fasted mice or to mice given ncomitantly olive oil or cysteine. Both agents being known to enhance absorption and bioavailability of oltipraz. Administration of olive oil with oltipraz exacerbated the effect of the mig on blood and on liver and lung histology. No such effect was evident when cysteine was given together with oltipraz. Fasting seems to abolish the effects produced by oltipraz in mice.
Keywords: The effects of olive oil, cysteine, or fasting on oltipraz Toxicity in mice